Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure

Elevated intraocular pressure (IOP) is the principal risk factor for glaucoma and results from excessive impedance of the fluid outflow from the eye. This abnormality likely originates from outflow pathway tissues such as the trabecular meshwork (TM), but the associated molecular etiology is poorly...

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Main Authors: Wang, Wan-Heng, McNatt, Loretta G., Pang, Iok-Hou, Millar, J. Cameron, Hellberg, Peggy E., Hellberg, Mark H., Steely, H. Thomas, Rubin, Jeffrey S., Fingert, John H., Sheffield, Val C., Stone, Edwin M., Clark, Abbot F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242621/
https://ncbi.nlm.nih.gov/pubmed/18274669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33871
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