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Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by abnormal expansion of glutamine (Q) encoding CAG repeats in the gene Ataxin-1 (ATXN1). Although motor and balance deficits are the core symptoms of SCA1, cognitive decline is also commonly observed in patients. While...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Asher, Melissa, Rosa, Juao-Guilherme, Rainwater, Orion, Duvick, Lisa, Bennyworth, Michael, Lai, Ruo-Yah, Kuo, Sheng-Han, Cvetanovic, Marija
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216071/
https://ncbi.nlm.nih.gov/pubmed/31696233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz265
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