Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα monoclonal antibodies

BACKGROUND: Mast cell and basophil activation by antigen crosslinking of FcεRI-bound IgE is central to allergy pathogenesis. We previously demonstrated global suppression of this process by rapid desensitization with anti-FcεRIα mAbs. OBJECTIVE: Determine whether use of monovalent (mv) anti-FcεRIα m...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Khodoun, Marat V., Morris, Suzanne C., Shao, Wen-Hai, Potter, Crystal, Angerman, Elizabeth, Kiselev, Artem, Yarawsky, Alexander E., Herr, Andrew B., Klausz, Katja, Otte, Anna, Peipp, Matthias, Finkelman, Fred D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215870/
https://ncbi.nlm.nih.gov/pubmed/33326804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.10.045
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