Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies

BACKGROUND: Anaphylaxis is classically mediated by allergen crosslinking of IgE bound to the α chain of FcεRI, the mast cell/basophil high affinity IgE receptor. Allergen crosslinking of the IgE/FcεRI complex activates these cells, inducing release of disease-causing mediators, cytokines and enzymes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Allergy Clin Immunol
Prif Awduron: Khodoun, Marat V., Morris, Suzanne C., Angerman, Elizabeth, Potter, Crystal, Schuman, Richard, Wunderlich, Mark, Maciag, Joseph J., Locker, Kathryn C. Sullivan, Mulloy, James C., Herr, Andrew B., Finkelman, Fred D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607676/
https://ncbi.nlm.nih.gov/pubmed/31836406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.12.003
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