Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies

BACKGROUND: Anaphylaxis is classically mediated by allergen crosslinking of IgE bound to the α chain of FcεRI, the mast cell/basophil high affinity IgE receptor. Allergen crosslinking of the IgE/FcεRI complex activates these cells, inducing release of disease-causing mediators, cytokines and enzymes...

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Vydáno v:J Allergy Clin Immunol
Hlavní autoři: Khodoun, Marat V., Morris, Suzanne C., Angerman, Elizabeth, Potter, Crystal, Schuman, Richard, Wunderlich, Mark, Maciag, Joseph J., Locker, Kathryn C. Sullivan, Mulloy, James C., Herr, Andrew B., Finkelman, Fred D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607676/
https://ncbi.nlm.nih.gov/pubmed/31836406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.12.003
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