Fibroblast Growth Factor Receptor 3 Alteration Status Is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma

BACKGROUND: Alterations in fibroblast growth factor receptor 3 (FGFR3) occur in ~15% of muscle-invasive bladder cancers (MIBCs) and metastatic urothelial carcinomas (mUCs). OBJECTIVE: To determine the association between FGFR3 status and response to platinum-based chemotherapy in patients with MIBC...

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Gepubliceerd in:Eur Urol
Hoofdauteurs: Teo, Min Yuen, Mota, Jose Mauricio, Whiting, Karissa A., Li, Han A., Funt, Samuel A., Lee, Chung-Han, Solit, David B., Al-Ahmadie, Hikmat, Milowsky, Matthew I., Balar, Arjun V., Pietzak, Eugene, Dalbagni, Guido, Bochner, Bernard H., Ostrovnaya, Irina, Bajorin, Dean F., Rosenberg, Jonathan E., Iyer, Gopa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215618/
https://ncbi.nlm.nih.gov/pubmed/32753285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2020.07.018
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