Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose N-glycan structure is essential for the uptak...

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Dades bibliogràfiques
Publicat a:Front Plant Sci
Autors principals: Uthailak, Naphatsamon, Kajiura, Hiroyuki, Misaki, Ryo, Fujiyama, Kazuhito
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Plant Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215604/
https://ncbi.nlm.nih.gov/pubmed/34163514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpls.2021.683762
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