Histone Methyltransferase SETD1A Induces Epithelial-Mesenchymal Transition to Promote Invasion and Metastasis Through Epigenetic Reprogramming of Snail in Gastric Cancer

Aberrant epigenetic modification induces oncogene expression and promotes cancer development. The histone lysine methyltransferase SETD1A, which specifically methylates histone 3 lysine 4 (H3K4), is involved in tumor growth and metastasis, and its ectopic expression has been detected in aggressive m...

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Publicado en:Front Cell Dev Biol
Autores principales: Wu, Jugang, Chai, Hongjuan, Shan, Haiyan, Pan, Chunpeng, Xu, Xin, Dong, Wenpei, Yu, Jiwei, Gu, Yan
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215546/
https://ncbi.nlm.nih.gov/pubmed/34164392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.657888
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