Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

Accumulating evidence indicates that the MDM2 oncoprotein promotes tumorigenesis beyond its canonical negative effects on the p53 tumor suppressor, but these p53-independent functions remain poorly understood. Here, we show that a fraction of endogenous MDM2 is actively imported in mitochondria to c...

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Publicat a:Mol Cell
Autors principals: Arena, Giuseppe, Cissé, Madi Yann, Pyrdziak, Samuel, Chatre, Laurent, Riscal, Romain, Fuentes, Maryse, Arnold, Jamie Jon, Kastner, Markus, Gayte, Laurie, Bertrand-Gaday, Christelle, Nay, Kevin, Angebault-Prouteau, Claire, Murray, Kerren, Chabi, Beatrice, Koechlin-Ramonatxo, Christelle, Orsetti, Béatrice, Vincent, Charles, Casas, François, Marine, Jean-Christophe, Etienne-Manneville, Sandrine, Bernex, Florence, Lombés, Anne, Cameron, Craig Eugene, Dubouchaud, Hervé, Ricchetti, Miria, Linares, Laetitia Karine, Le Cam, Laurent
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215449/
https://ncbi.nlm.nih.gov/pubmed/29452639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.023
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