Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

The cardiac sodium–calcium exchanger (NCX1) is important for normal Na(+)- and Ca(2+)-homeostasis and cardiomyocyte relaxation and contraction. It has been suggested that NCX1 activity is reduced by phosphorylated phospholemman (pSer68-PLM); however its direct interaction with PLM is debated. Disrup...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Wanichawan, Pimthanya, Skogestad, Jonas, Lunde, Marianne, Støle, Thea Parsberg, Stensland, Maria, Nyman, Tuula A., Sjaastad, Ivar, Sejersted, Ole M., Aronsen, Jan Magnus, Carlson, Cathrine Rein
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215385/
https://ncbi.nlm.nih.gov/pubmed/34163352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.638646
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