Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase

Pyridoxal 5’-phosphate (PLP), the catalytically active form of vitamin B(6), plays a pivotal role in metabolism as an enzyme cofactor. PLP is a very reactive molecule and can be very toxic unless its intracellular concentration is finely regulated. In Escherichia coli, PLP formation is catalyzed by...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Barile, Anna, Battista, Theo, Fiorillo, Annarita, di Salvo, Martino Luigi, Malatesta, Francesco, Tramonti, Angela, Ilari, Andrea, Contestabile, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215295/
https://ncbi.nlm.nih.gov/pubmed/34019876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100795
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