Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice

DYT-TOR1A or DYT1 early-onset generalized dystonia is an inherited movement disorder characterized by sustained muscle contractions causing twisting, repetitive movements, or abnormal postures. The majority of the DYT1 dystonia patients have a trinucleotide GAG deletion in DYT1/TOR1A. Trihexyphenidy...

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Detalhes bibliográficos
Publicado no:IBRO Neurosci Rep
Main Authors: Yokoi, Fumiaki, Dang, Mai Tu, Zhang, Lin, Dexter, Kelly M., Efimenko, Iakov, Krishnaswamy, Shiv, Villanueva, Matthew, Misztal, Carly I., Gerard, Malinda, Lynch, Patrick, Li, Yuqing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215213/
https://ncbi.nlm.nih.gov/pubmed/34189496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibneur.2021.05.003
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