Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrP(C)

Expression of the cellular prion protein (PrP(C)) is crucial for the development of prion diseases. Amino acid changes in PrP(C) or a reduced amount of PrP(C) may modulate disease resistance. The relative abundance of C1, a natural α-cleavage fragment of PrP(C), was previously found to be associated...

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Publicat a:Genet Sel Evol
Autors principals: Madsen-Bouterse, Sally A., Stewart, Paula, Williamson, Helen, Schneider, David A., Goldmann, Wilfred
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214774/
https://ncbi.nlm.nih.gov/pubmed/34147084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12711-021-00646-x
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