Lataa...
ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy
TANK-binding kinase 1 (TBK1) is a multifunctional kinase with an essential role in mitophagy, the selective clearance of damaged mitochondria. More than 90 distinct mutations in TBK1 are linked to amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia, including missense mutations that dis...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2021
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8214690/ https://ncbi.nlm.nih.gov/pubmed/34099552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025053118 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|