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Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
Mitochondria play an essential role in maintaining cellular homeostasis. The removal of damaged or depolarized mitochondria occurs via mitophagy, in which damaged mitochondria are targeted for degradation via ubiquitination induced by PTEN-induced putative kinase 1 (PINK1) and Parkin. Mitophagy rece...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914160/ https://ncbi.nlm.nih.gov/pubmed/27247382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523810113 |
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