Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir

Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that are otherwise occluded on the unliganded viral envelope (Env). Combining CD4mc with two families of CD4-induced (CD4i) antibodie...

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Gepubliceerd in:Cell Host Microbe
Hoofdauteurs: Rajashekar, Jyothi K, Richard, Jonathan, Beloor, Jagadish, Prévost, Jérémie, Anand, Sai Priya, Beaudoin-Bussières, Guillaume, Shan, Liang, Herndler-Brandstetter, Dietmar, Gendron-Lepage, Gabrielle, Medjahed, Halima, Bourassa, Catherine, Gaudette, Fleur, Ullah, Irfan, Symmes, Kelly, Peric, Andrew, Lindemuth, Emily, Bibollet-Ruche, Frederic, Park, Jun, Chen, Hung-Ching, Kaufmann, Daniel E, Hahn, Beatrice H., Sodroski, Joseph, Pazgier, Marzena, Flavell, Richard A., Smith, Amos B, Finzi, Andrés, Kumar, Priti
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214472/
https://ncbi.nlm.nih.gov/pubmed/34019804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2021.04.014
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