Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

The whooping cough agent Bordetella pertussis secretes an adenylate cyclase toxin (CyaA) that through its large carboxy-proximal Repeat-in-ToXin (RTX) domain binds the complement receptor 3 (CR3). The RTX domain consists of five blocks (I–V) of characteristic glycine and aspartate-rich nonapeptides...

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發表在:J Biol Chem
Main Authors: Espinosa-Vinals, Carlos Angel, Masin, Jiri, Holubova, Jana, Stanek, Ondrej, Jurnecka, David, Osicka, Radim, Sebo, Peter, Bumba, Ladislav
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214218/
https://ncbi.nlm.nih.gov/pubmed/34051233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100833
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