The use of extrapolation based on modeling and simulation to support high‐dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft‐tissue infections

A model‐informed drug development approach was used to select ceftaroline fosamil high‐dose regimens for pediatric patients with complicated skin and soft‐tissue infections caused by Staphylococcus aureus with a ceftaroline minimum inhibitory concentration (MIC) of 2 or 4 mg/L. Steady‐state ceftarol...

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Veröffentlicht in:CPT Pharmacometrics Syst Pharmacol
Hauptverfasser: Chan, Phylinda L.S., McFadyen, Lynn, Quaye, Andrea, Leister‐Tebbe, Heidi, Hendrick, Victoria M., Hammond, Jennifer, Raber, Susan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213416/
https://ncbi.nlm.nih.gov/pubmed/33687148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12608
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