Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss

Prior studies demonstrated that deletion of the protein phosphatase Phlpp1 in Ctsk-Cre expressing cells enhances bone mass, characterized by diminished osteoclast activity and increased coupling to bone formation. Due to non-specific expression of Ctsk-Cre, the definitive mechanism for this observat...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hanson, Marcelline K., Karkache, Ismael Y., Molstad, David H. H., Norton, Andrew A., Mansky, Kim C., Bradley, Elizabeth W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213150/
https://ncbi.nlm.nih.gov/pubmed/34143773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251732
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