Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice

Loss of ovarian function is closely related to estrogen (E(2)) deficiency, which is responsible for increased osteoclast (OC) differentiation and activity. We aimed to investigate the action mechanism of E(2) to decrease bone resorption in OCs to protect from ovariectomy (OVX)-induced bone loss in m...

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Bibliographic Details
Published in:Antioxidants (Basel)
Main Authors: Park, Hyun-Jung, Gholam-Zadeh, Malihatosadat, Yoon, Sun-Young, Suh, Jae-Hee, Choi, Hye-Seon
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073670/
https://ncbi.nlm.nih.gov/pubmed/33920630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10040619
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