Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss

Lycorine, a plant alkaloid, exhibits anti-inflammatory activity by acting in macrophages that share precursor cells with osteoclasts (OCs). We hypothesized that lycorine might decrease bone loss by acting in OCs after lipopolysaccharide (LPS) stimulation, since OCs play a main role in LPS-induced bo...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Park, Hyun-Jung, Gholam-Zadeh, Malihatosadat, Suh, Jae-Hee, Choi, Hye-Seon
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800915/
https://ncbi.nlm.nih.gov/pubmed/31687088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8982147
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