Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss

Lycorine, a plant alkaloid, exhibits anti-inflammatory activity by acting in macrophages that share precursor cells with osteoclasts (OCs). We hypothesized that lycorine might decrease bone loss by acting in OCs after lipopolysaccharide (LPS) stimulation, since OCs play a main role in LPS-induced bo...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Park, Hyun-Jung, Gholam-Zadeh, Malihatosadat, Suh, Jae-Hee, Choi, Hye-Seon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800915/
https://ncbi.nlm.nih.gov/pubmed/31687088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8982147
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