Clinical Validation of a Quantitative HIV-1 DNA Droplet Digital PCR assay: Applications for Detecting Occult HIV-1 Infection and Monitoring Cell-associated HIV-1 Dynamics across Different Subtypes in HIV-1 Prevention and Cure Trials

BACKGROUND. In HIV-1-exposed infants, nucleic acid testing (NAT) is required to diagnose infection since passively transferred maternal antibodies preclude antibody testing. The sensitivity of clinical NAT assays is lowered with infant antiretroviral prophylaxis and, with empiric very early antiretr...

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Pubblicato in:J Clin Virol
Autori principali: Powell, Laura, Dhummakupt, Adit, Siems, Lilly, Singh, Dolly, Le Duff, Yann, Uprety, Priyanka, Jennings, Cheryl, Szewczyk, Joseph, Chen, Ya, Nastouli, Eleni, Persaud, Deborah
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212401/
https://ncbi.nlm.nih.gov/pubmed/33930698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcv.2021.104822
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