The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia

The oncogenic transcription factor TAL1 regulates the transcriptional program in T-ALL. ARID5B is one of the critical downstream targets of TAL1, which further activates the oncogenic regulatory circuit in T-ALL cells. Here, we elucidated the molecular functions of the noncoding RNA, ARID5B-inducing...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Tan, Shi Hao, Leong, Wei Zhong, Ngoc, Phuong Cao Thi, Tan, Tze King, Bertulfo, Fatima Carla, Lim, Mei Chee, An, Omer, Li, Zhenhua, Yeoh, Allen Eng Juh, Fullwood, Melissa J., Tenen, Daniel G., Sanda, Takaomi
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212351/
https://ncbi.nlm.nih.gov/pubmed/31076442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018874503
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