Prosaposin mediates inflammation in atherosclerosis

Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties of these cells are dictated by their metabolism, of which the mechanistic target of rapamycin (mTOR) signaling pathway is a key regulator. Using myeloid cell-specific nanobiologics in apolipoprotein E...

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Vydáno v:Sci Transl Med
Hlavní autoři: van Leent, Mandy M.T., Beldman, Thijs J., Toner, Yohana C., Lameijer, Marnix A., Rother, Nils, Bekkering, Siroon, Teunissen, Abraham J.P., Zhou, Xianxiao, van der Meel, Roy, Malkus, Joost, Nauta, Sheqouia A., Klein, Emma D., Fay, Francois, Sanchez-Gaytan, Brenda L., Pérez-Medina, Carlos, Kluza, Ewelina, Ye, Yu-Xiang, Wojtkiewicz, Gregory, Fisher, Edward A., Swirski, Filip K., Nahrendorf, Matthias, Zhang, Bin, Li, Yang, Zhang, Bowen, Joosten, Leo A.B., Pasterkamp, Gerard, Boltjes, Arjan, Fayad, Zahi A., Lutgens, Esther, Netea, Mihai G., Riksen, Niels P., Mulder, Willem J.M., Duivenvoorden, Raphaël
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209679/
https://ncbi.nlm.nih.gov/pubmed/33692130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abe1433
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