Prosaposin mediates inflammation in atherosclerosis

Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties of these cells are dictated by their metabolism, of which the mechanistic target of rapamycin (mTOR) signaling pathway is a key regulator. Using myeloid cell-specific nanobiologics in apolipoprotein E...

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Publicado no:Sci Transl Med
Main Authors: van Leent, Mandy M.T., Beldman, Thijs J., Toner, Yohana C., Lameijer, Marnix A., Rother, Nils, Bekkering, Siroon, Teunissen, Abraham J.P., Zhou, Xianxiao, van der Meel, Roy, Malkus, Joost, Nauta, Sheqouia A., Klein, Emma D., Fay, Francois, Sanchez-Gaytan, Brenda L., Pérez-Medina, Carlos, Kluza, Ewelina, Ye, Yu-Xiang, Wojtkiewicz, Gregory, Fisher, Edward A., Swirski, Filip K., Nahrendorf, Matthias, Zhang, Bin, Li, Yang, Zhang, Bowen, Joosten, Leo A.B., Pasterkamp, Gerard, Boltjes, Arjan, Fayad, Zahi A., Lutgens, Esther, Netea, Mihai G., Riksen, Niels P., Mulder, Willem J.M., Duivenvoorden, Raphaël
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209679/
https://ncbi.nlm.nih.gov/pubmed/33692130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abe1433
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