MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder. Cholesterol 25-hydroxylase (CH25H) was proved to play a key role in cartilage cholesterol metabolism. However, the biol...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Li, Xiaochen, Zhang, Li, Shi, Xiaoqing, Liao, Taiyang, Zhang, Nongshan, Gao, Yifan, Xing, Runlin, Wang, Peimin
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209416/
https://ncbi.nlm.nih.gov/pubmed/34149433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.690181
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