MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder. Cholesterol 25-hydroxylase (CH25H) was proved to play a key role in cartilage cholesterol metabolism. However, the biol...

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Publicado en:Front Pharmacol
Autores principales: Li, Xiaochen, Zhang, Li, Shi, Xiaoqing, Liao, Taiyang, Zhang, Nongshan, Gao, Yifan, Xing, Runlin, Wang, Peimin
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209416/
https://ncbi.nlm.nih.gov/pubmed/34149433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.690181
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