Extracellular mRNA transported to the nucleus exerts translation-independent function

RNA in extracellular vesicles (EVs) are uptaken by cells, where they regulate fundamental cellular functions. EV-derived mRNA in recipient cells can be translated. However, it is still elusive whether “naked nonvesicular extracellular mRNA” (nex-mRNA) that are not packed in EVs can be uptaken by cel...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tomita, Takeshi, Kato, Masayoshi, Mishima, Taishi, Matsunaga, Yuta, Sanjo, Hideki, Ito, Ken-ichi, Minagawa, Kentaro, Matsui, Toshimitsu, Oikawa, Hiroyuki, Takahashi, Satoshi, Takao, Toshifumi, Iwai, Noriki, Mino, Takashi, Takeuchi, Osamu, Maru, Yoshiro, Hiratsuka, Sachie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208975/
https://ncbi.nlm.nih.gov/pubmed/34135341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23969-1
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