Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types

Amongst the pleotropic roles of transforming growth factor β (TGFβ) signaling in cancer, its impact on genomic stability is least understood. Inhibition of TGFβ signaling increases use of alternative end-joining (alt-EJ), an error-prone DNA repair process that typically functions as a ‘backup’ pathw...

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Publicado no:Sci Transl Med
Main Authors: Liu, Qi, Palomero, Luis, Moore, Jade, Guix, Ines, Espin, Roderic, Aytés, Alvaro, Mao, Jian-Hua, Paulovich, Amanda G., Whiteaker, Jeffrey R., Ivey, Richard G., Iliakis, George, Luo, Daxian, Chalmers, Anthony J., Murnane, John, Pujana, Miquel Angel, Barcellos-Hoff, Mary Helen
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208885/
https://ncbi.nlm.nih.gov/pubmed/33568520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abc4465
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