Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features governing G protein selectivity and promiscuity are cur...

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Detalles Bibliográficos
Publicado en:PLoS Biol
Main Authors: Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
Assuntos:
Discovery Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208569/
https://ncbi.nlm.nih.gov/pubmed/34086670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001295
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