Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features governing G protein selectivity and promiscuity are cur...

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Sparad:
Bibliografiska uppgifter
I publikationen:PLoS Biol
Huvudupphovsmän: Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2021
Ämnen:
Discovery Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208569/
https://ncbi.nlm.nih.gov/pubmed/34086670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001295
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