Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features governing G protein selectivity and promiscuity are cur...

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Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J., Sexton, Patrick M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
Soggetti:
Discovery Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208569/
https://ncbi.nlm.nih.gov/pubmed/34086670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001295
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