The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols

Vinyl- and ethynyl phosphorus(v) electrophiles are a versatile class of thiol-reactive reagents suitable for cysteine-selective peptide and protein modifications, especially for the generation of antibody conjugates. Herein we investigated the reactivity of various P(v) reagents towards thiol additi...

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Vydáno v:Chem Sci
Hlavní autoři: Park, Yerin, Baumann, Alice L., Moon, Hyejin, Byrne, Stephen, Kasper, Marc-André, Hwang, Songhwan, Sun, Han, Baik, Mu-Hyun, Hackenberger, Christian P. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2021
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208129/
https://ncbi.nlm.nih.gov/pubmed/34194704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01730f
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