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Monohalogenated acetamide induced cellular stress and genotoxicity is related to electrophilic softness and thiol/thiolate reactivity.

Haloacetamides (HAMs) are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an S(N)2 reaction mechanism. Toxicity of the monohalogenated HAMs (iodoace...

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Detalhes bibliográficos
Publicado no:J Environ Sci (China)
Main Authors: Pals, Justin A., Wagner, Elizabeth D., Plewa, Michael J., Xia, Menghang, Attene-Ramos, Matias S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239421/
https://ncbi.nlm.nih.gov/pubmed/28774613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jes.2017.04.027
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