Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression

BACKGROUND: The effects of non-amplification short variant (SV) mutations in CD274 (programmed death-ligand 1 (PD-L1)) on PD-L1 protein expression and immune checkpoint inhibitors (ICPIs) therapy are unknown. Here, we present a retrospective analysis of CD274 mutations detected by comprehensive geno...

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Publicado en:J Immunother Cancer
Autores principales: Huang, Richard S.P., Decker, Brennan, Murugesan, Karthikeyan, Hiemenz, Matthew, Mata, Douglas A., Li, Gerald, Creeden, James, Ramkissoon, Shakti H., Ross, Jeffrey S.
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2021
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8207995/
https://ncbi.nlm.nih.gov/pubmed/34130989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002558
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