Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer

PURPOSE: Programmed death ligand-1 (PD-L1), encoded by the CD274 gene, is a target for immune checkpoint blockade; however, little is known about genomic CD274 alterations. A subset of small-cell lung cancer (SCLC) exhibits increased copy number of chromosome 9p24, on which CD274 resides; however, m...

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I publikationen:Clin Cancer Res
Huvudupphovsmän: George, Julie, Saito, Motonobu, Tsuta, Koji, Iwakawa, Reika, Shiraishi, Kouya, Scheel, Andreas H., Uchida, Shinsuke, Watanabe, Shun-ichi, Nishikawa, Ryo, Noguchi, Masayuki, Peifer, Martin, Jang, Se Jin, Petersen, Iver, Büttner, Reinhard, Harris, Curtis C., Yokota, Jun, Thomas, Roman K., Kohno, Takashi
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329376/
https://ncbi.nlm.nih.gov/pubmed/27620277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1069
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