Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila

BACKGROUND: The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila. Unlike known monoterpene indole alkaloids, CPT in C. acuminata is biosynthesized via the key intermediate strictosidinic acid,...

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Detalles Bibliográficos
Publicado en:BMC Biol
Main Authors: Yang, Mengquan, Wang, Qiang, Liu, Yining, Hao, Xiaolong, Wang, Can, Liang, Yuchen, Chen, Jianbo, Xiao, Youli, Kai, Guoyin
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8207662/
https://ncbi.nlm.nih.gov/pubmed/34134716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-021-01051-y
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