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Regulation of EAE by spontaneously generated IL‐10‐secreting regulatory T cells in HLA‐DR15/TCR.Ob1A12 double transgenic mice
Humanized double transgenic mice express both HLA‐DR15 (the MHC gene linked to MS) and TCR.Ob1A12 from a multiple sclerosis patient (that recognizes MBP85‐99 presented by HLA‐DR15), yet they fail to develop autoimmune encephalomyelitis quickly, although 5–10% develop disease at 12 months. These mice...
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| Publicado no: | Immunology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8207442/ https://ncbi.nlm.nih.gov/pubmed/33565605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13321 |
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