Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy

Obese men have lower circulating testosterone than men with an optimal body mass index. Elevated fatty acids (FAs) caused by obesity have been reported to suppress the steroidogenesis of Leydig cells. Recent studies have demonstrated that autophagy regulates steroidogenesis in endocrine cells; howev...

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Publicado no:Sci Rep
Main Authors: Huang, Chien, Hsu, Hsiu-Ju, Wang, Mu-En, Hsu, Meng-Chieh, Wu, Leang-Shin, Jong, De-Shien, Jiang, Yi-Fan, Chiu, Chih-Hsien
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206377/
https://ncbi.nlm.nih.gov/pubmed/34131222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92008-2
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