Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy

Obese men have lower circulating testosterone than men with an optimal body mass index. Elevated fatty acids (FAs) caused by obesity have been reported to suppress the steroidogenesis of Leydig cells. Recent studies have demonstrated that autophagy regulates steroidogenesis in endocrine cells; howev...

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Vydáno v:Sci Rep
Hlavní autoři: Huang, Chien, Hsu, Hsiu-Ju, Wang, Mu-En, Hsu, Meng-Chieh, Wu, Leang-Shin, Jong, De-Shien, Jiang, Yi-Fan, Chiu, Chih-Hsien
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206377/
https://ncbi.nlm.nih.gov/pubmed/34131222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92008-2
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