Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: a phenome-wide association study and inverse-variance weighted meta-analysis

OBJECTIVES: To test the hypothesis that genetic predisposition to systemic lupus erythematosus (SLE) increases the risk of cardiometabolic disorders. METHODS: Using 41 single nucleotide polymorphisms (SNPs) associated with SLE, we calculated a weighted genetic risk score (wGRS) for SLE. In a large b...

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Pubblicato in:Lupus
Autori principali: Kawai, Vivian K., Shi, Mingjian, Liu, Ge, Feng, QiPing, Wei, WeiQi, Chung, Cecilia P., Walunas, Theresa L., Gordon, Adam S., Linneman, James G., Hebbring, Scott J., Harley, John B., Cox, Nancy J., Roden, Dan M., Stein, C. Michael, Mosley, Jonathan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205989/
https://ncbi.nlm.nih.gov/pubmed/33977795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/09612033211014952
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