Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: a phenome-wide association study and inverse-variance weighted meta-analysis

OBJECTIVES: To test the hypothesis that genetic predisposition to systemic lupus erythematosus (SLE) increases the risk of cardiometabolic disorders. METHODS: Using 41 single nucleotide polymorphisms (SNPs) associated with SLE, we calculated a weighted genetic risk score (wGRS) for SLE. In a large b...

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Publicat a:Lupus
Autors principals: Kawai, Vivian K., Shi, Mingjian, Liu, Ge, Feng, QiPing, Wei, WeiQi, Chung, Cecilia P., Walunas, Theresa L., Gordon, Adam S., Linneman, James G., Hebbring, Scott J., Harley, John B., Cox, Nancy J., Roden, Dan M., Stein, C. Michael, Mosley, Jonathan D.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205989/
https://ncbi.nlm.nih.gov/pubmed/33977795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/09612033211014952
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