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Chimeric Zika viruses containing structural protein genes of insect-specific flaviviruses cannot replicate in vertebrate cells due to entry and post-translational restrictions

Long Pine Key virus (LPKV) and Lammi virus are insect-specific flaviviruses that phylogenetically affiliate with dual-host flaviviruses. The goal of this study was to provide insight into the genetic determinants that condition this host range restriction. Chimeras were initially created by replacin...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Tangudu, Chandra S., Charles, Jermilia, Nunez-Avellaneda, Daniel, Hargett, Alissa M., Brault, Aaron C., Blitvich, Bradley J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205982/
https://ncbi.nlm.nih.gov/pubmed/33812340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2021.03.014
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