Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity

OBJECTIVE: To investigate the influence of heterogeneity in disease progression for detecting treatment effects in Alzheimer disease (AD) trials, using a simulation study. METHODS: Individuals with an abnormal amyloid PET scan, diagnosis of mild cognitive impairment or dementia, baseline Mini-Mental...

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Udgivet i:Neurology
Main Authors: Jutten, Roos J., Sikkes, Sietske A.M., Van der Flier, Wiesje M., Scheltens, Philip, Visser, Pieter Jelle, Tijms, Betty M.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205463/
https://ncbi.nlm.nih.gov/pubmed/34550903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000012022
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