Synthesis, Radiolabeling, and Biological Evaluation of the trans-Stereoisomers of 1-Amino-3-(fluoro-(18)F)-4-fluorocyclopentane-1-carboxylic Acid as PET Imaging Agents

[Image: see text] The enantiomeric non-natural cyclic amino acids (3R,4R)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid and (3S,4S)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]5) have been prepared as a racemic mixture in 1.3% decay corrected radiochemic...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Pickel, Thomas C., Pashikanti, Gouthami, Voll, Ronald J., Yu, Weiping, Zhang, Zhaobin, Nye, Jonathon A., Bacsa, John, Olson, Jeffrey J., Liebeskind, Lanny S., Goodman, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205243/
https://ncbi.nlm.nih.gov/pubmed/34151209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00062
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