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Synthesis, Radiolabeling and Biological Evaluation of (R)- and (S)-2-Amino-3-[(18)F]Fluoro-2-Methylpropanoic Acid (FAMP) and (R)- and (S)-3-[(18)F]Fluoro-2-Methyl-2-N-(Methylamino)propanoic Acid (NMeFAMP) as Potential PET Radioligands for Imaging Brain Tumors
The non-natural amino acids (R)- and (S)-2-amino-3-fluoro-2-methylpropanoic acid 5 and (R)- and (S)-3-fluoro-2-methyl-2-N-(methylamino)propanoic acid 8 were synthesized in shorter reaction sequences than in the original report starting from enantiomerically pure (S)- and (R)-α-methyl-serine, respect...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836592/ https://ncbi.nlm.nih.gov/pubmed/20028004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900556s |
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