Targeting effector pathways in RAC1(P29S)-driven malignant melanoma

Malignant melanoma is characterized by mutations in a number of driver genes, most notably BRAF and NRAS. Recent genomic analyses revealed that 4-9% of sun-exposed melanomas bear activating mutations in RAC1, which encodes a small GTPase that is known to play key roles in cell proliferation, surviva...

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Bibliographische Detailangaben
Veröffentlicht in:Small GTPases
Hauptverfasser: Uribe-Alvarez, Cristina, Guerrero-Rodríguez, Sandra Lucía, Rhodes, Jennifer, Cannon, Alexa, Chernoff, Jonathan, Araiza-Olivera, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205048/
https://ncbi.nlm.nih.gov/pubmed/32043900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2020.1728469
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