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Empirical Bayes shrinkage and false discovery rate estimation, allowing for unwanted variation

We combine two important ideas in the analysis of large-scale genomics experiments (e.g. experiments that aim to identify genes that are differentially expressed between two conditions). The first is use of Empirical Bayes (EB) methods to handle the large number of potentially-sparse effects, and es...

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Bibliografiske detaljer
Udgivet i:Biostatistics
Main Authors: Gerard, David, Stephens, Matthew
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204175/
https://ncbi.nlm.nih.gov/pubmed/29985984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxy029
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