A MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation

BACKGROUND: Functions of miRNAs involved in tumorigenesis are well reported, yet, their roles in normal cell lineage commitment remain ambiguous. Here, we investigated a specific “transcription factor (TF)-miRNA-Target” regulatory network during the lineage maturation of biliary tree stem cells (BTS...

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Dettagli Bibliografici
Pubblicato in:Front Cell Dev Biol
Autori principali: Wang, Xicheng, Zhang, Wencheng, Yang, Yong, Wang, Jiansong, Qiu, Hua, Liao, Lijun, Oikawa, Tsunekazu, Wauthier, Eliane, Sethupathy, Praveen, Reid, Lola M., Liu, Zhongmin, He, Zhiying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204022/
https://ncbi.nlm.nih.gov/pubmed/34141708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.670059
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