Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis

Rodent cancer bioassays indicate that the aryl hydrocarbon receptor (AHR) agonist, 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD), causes increases in both hepatocytic and cholangiocytic tumors. Effects of AHR activation have been evaluated on rodent hepatic stem cells (rHpSCs) versus their descendants...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Harrill, Joshua A, Parks, Bethany B, Wauthier, Eliane, Rowlands, J Craig, Reid, Lola M, Thomas, Russell S
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Hepatobiliary Malignancies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303521/
https://ncbi.nlm.nih.gov/pubmed/25284723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27547
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