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Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding

Aryl hydrocarbon hydroxylase is present and is inducible in mouse skin. 7,8-Benzoflavone, an inhibitor of the enzyme, markedly inhibits tumorigenesis by 7,12-dimethylbenz(a)anthracene, but has either no effect on or stimulates benzo(a)pyrene tumorigenesis. Thus, the role of aryl hydrocarbon hydroxyl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kinoshita, Nadao, Gelboin, Harry V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1972
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426573/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4502935/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.4.824
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